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Focal Segmental Glomerulosclerosis (FSGS) iPSCs and clinical data

We’re happy to share that the iPSC lines from the study “Generation of 20 Human Induced Pluripotent Stem Cell Lines from Patients with Focal Segmental Glomerulosclerosis (FSGS)” are available through EBiSC!

These iPSC lines, derived from patients with FSGS, provide a valuable resource for studying kidney disease mechanisms and testing potential therapies. Detailed clinical data is available upon request for researchers looking to deepen their understanding of FSGS.

Explore the iPSC lines and access data via EBiSC here to drive forward your nephrology research.

#FSGS #iPSC #KidneyResearch #EBiSC #GeneticResearch #DiseaseModeling #Nephrology #RegenerativeMedicine

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Exciting Partnership Announcement: EBISC Teams Up with Sampled to Support USA Shipments for iPSC Resources

Exciting Partnership Announcement: EBISC Teams Up with Sampled to Support USA Shipments for iPSC Resources

EBISC (European Bank for Induced Pluripotent Stem Cells) has teamed up with Sampled, a global leader in biorepository and laboratory services, to enhance distribution capabilities for American researchers.

What This Means for Researchers

For American researchers, this partnership will simplify the procurement process for iPSC resources, allowing them to focus more on their research objectives and less on logistics. The enhanced local distribution ensures that high-quality samples can be efficiently shipped, helping to save time and reducing the cost of shipping.

Looking Ahead

As this exciting collaboration unfolds, we are confident that it will significantly improve the availability and accessibility of iPSC resources for researchers in the United States. This partnership represents a key step toward creating a more connected and efficient global research ecosystem.

Stay tuned for further updates on how EBISC and Sampled are working together to support scientific discovery and innovation. We look forward to seeing the incredible advancements that will come from this new chapter in research collaboration.

For more information on how this partnership will benefit your research, visit EBISC and Sampled.

EBiSC – European Bank for Induced pluripotent Stem Cells

Sampled – Any Sample, Every Answer.

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New publication on EBiSC-NEUR1 neurons!

We’re thrilled to see the paper “Measurements of Neurite Extension and Nucleokinesis in an iPSC-Derived Model System Following Microtubule Perturbation” published, showcasing the power of EBiSC iPSC-derived neurons.

This study highlights how iPSC technology can be used to model and measure key cellular processes like neurite extension and nucleokinesis, offering valuable insights into neurodevelopmental diseases. It’s exciting to see how EBiSC-generated iPSC lines are contributing to cutting-edge research that deepens our understanding of cellular dynamics and disease mechanisms.

https://pubmed.ncbi.nlm.nih.gov/39602292

#iPSC #Neurodegeneration #Neuroscience #EBiSC #DiseaseModeling #StemCellResearch #Neurodevelopment

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Simplified and secure access to genomic data at EBiSC.

At EBiSC, we’re constantly working to make it easier for researchers to access and use our valuable resources. That’s why we’ve streamlined the process for requesting and accessing genomic data associated with our iPSC lines.

Via EGA, researchers can now easily request genomic datasets linked to our iPSC lines, including genomic, and clinical data. We’ve worked hard to ensure that this data is not only comprehensive but also easily accessible, so researchers can focus on what matters most: advancing their research.

Our goal is to make high-quality iPSC resources and data available to the scientific community to drive innovation and accelerate discoveries in disease modelling, drug development, and personalized medicine.

Ready to get started? Visit https://ega-archive.org/search/EBiSC to explore the datasets and find more information on requesting access at https://ebisc.org/data/Managed_access_datasets

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A panel of robust and well characterised iPSC lines from apparently healthy backgrounds.

We understand that finding the perfect, well-characterised iPSC line from a healthy background can be a challenge. That’s why EBiSC has curated a special panel of robust iPSC lines—covering both male and female genetic backgrounds and generated using various reprogramming methods—to make your research easier. Explore the full panel of healthy iPSC lines here and reach out if you have any questions—we’re here to help!

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New publication: “The Management of Data for the Banking, Qualification, and Distribution of Induced Pluripotent Stem Cells: Lessons Learned from the European Bank for Induced Pluripotent Stem Cells”

We’re excited to announce the publication of our new paper: “The Management of Data for the Banking, Qualification, and Distribution of Induced Pluripotent Stem Cells: Lessons Learned from the European Bank for Induced Pluripotent Stem Cells”.

This paper provides valuable insights into how EBiSC and the human Pluripotent Stem Cell registry work together to ensure a robust and secure data management platform and present a model for how this could be implemented by other iPSC repositories to increase the FAIRness of iPSC research globally.

This open access publication is linked below – thanks to all authors for their contributions.

https://pmc.ncbi.nlm.nih.gov/articles/PMC10705942

#iPSCs #FAIR #Data #Biobanking

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A Christmas message from EBiSC

After a very busy year, EBiSC is now entering its next stage as a sustainable scientific repository! Since its inception, EBiSC has garnered a wealth of expertise through the dedication of key partners. This has been maintained via the continued participation of myself at Fraunhofer UK and of the team at Fraunhofer-IBMT, both of whom have been with EBiSC since its inception in 2014. I am delighted to announce that Fraunhofer-UK now spearheads EBiSC, serving as the primary point of contact for users and collaborators, supported by the scientific banking, cryostorage and hPSCreg teams at Fraunhofer-IBMT (both operating as not-for-profit organisations). Moving forward, orders will be processed by Fraunhofer UK, in Scotland, while Fraunhofer-IBMT in Germany will manage the central and mirror storage of cells. EBiSC remains steadfast in its commitment as a not-for-profit repository, diligently collecting and sharing a diverse collection of iPS cell lines, enabling accessibility for researchers worldwide. With this in mind, from the start of 2024 onwards, customers will be able to order directly from the EBiSC catalogue.

EBiSC was initially founded through the collaborative undertaking of large European consortia, funded jointly by the Innovative Medicines Initiative (IMI) of the European Union (EU), and members of the European Federation of Pharmaceutical Industries and Associations (EFPIA). Whilst the first funded project phase, “EBiSC” worked to establish a working infrastructure and framework for the bank, a second phase, “EBiSC2”, aimed to ensure the implemented biobanking framework was robust, sustainable and able to continue operating long term. See more information about the history of EBiSC here.

During EBiSC2, core biobanking operations were performed by Fraunhofer IBMT, Fraunhofer UK and the European Collection of Authenticated Cell Cultures (ECACC, part of the UK Health Security Agency). Whilst ECACC steps away from EBiSC to focus on other developments, we are thankful for their support in implementing the plan for sustainability and I would like to say a big thank you to the whole ECACC team for their time and support during this process. Indeed, we are grateful to all EBiSC and EBiSC2 partners who committed time and energy into not only building the bank, but into making sure that EBiSC can continue collecting and sharing iPS cells and data and providing services to the research community.

EBiSC has many exciting developments in progress and I am looking forward to sharing these during 2024! Wishing you all a very merry Christmas and a great end to the year.

For inquiries or collaboration opportunities with EBiSC, please do not hesitate to reach out.

Best,

Dr Rachel Steeg

Head of EBiSC

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A new EBiSC iPSC-derived neuronal cell product simplifies neuroscience research

The possibility to generate an unlimited amount of mature and functionally active neurons from human- induced pluripotent stem cells (iPSCs) has the potential to radically accelerate neuroscience research. However, differentiation protocols can be lengthy, expensive, and often produce inconsistencies in terms of yield and functionality. The European Bank for induced Pluripotent Stem Cells (EBiSC) is happy to announce a new iPSC derived neuronal cell product – EBiSC-NEUR1 which can be used directly from thaw for downstream applications.

https://ebisc.org/EBISC-NEUR1

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Protocol for the use of induced pluripotent stem cells

An updated version of the EBiSC protocol for the use of induced pluripotent stem cells is now available online. This document provides guidance on how to resuscitate, culture and cryopreserve human induced pluripotent stem cells (iPSCs) supplied by EBiSC.

https://ebisc.org/docs/ebisc/EBiSC_User_Protocol_for_Human_induced_Pluripotent_Stem_Cells.pdf