Posted on Leave a comment

New publication on EBiSC-NEUR1 neurons!

We’re thrilled to see the paper “Measurements of Neurite Extension and Nucleokinesis in an iPSC-Derived Model System Following Microtubule Perturbation” published, showcasing the power of EBiSC iPSC-derived neurons.

This study highlights how iPSC technology can be used to model and measure key cellular processes like neurite extension and nucleokinesis, offering valuable insights into neurodevelopmental diseases. It’s exciting to see how EBiSC-generated iPSC lines are contributing to cutting-edge research that deepens our understanding of cellular dynamics and disease mechanisms.

https://pubmed.ncbi.nlm.nih.gov/39602292

#iPSC #Neurodegeneration #Neuroscience #EBiSC #DiseaseModeling #StemCellResearch #Neurodevelopment

Posted on Leave a comment

Simplified and secure access to genomic data at EBiSC.

At EBiSC, we’re constantly working to make it easier for researchers to access and use our valuable resources. That’s why we’ve streamlined the process for requesting and accessing genomic data associated with our iPSC lines.

Via EGA, researchers can now easily request genomic datasets linked to our iPSC lines, including genomic, and clinical data. We’ve worked hard to ensure that this data is not only comprehensive but also easily accessible, so researchers can focus on what matters most: advancing their research.

Our goal is to make high-quality iPSC resources and data available to the scientific community to drive innovation and accelerate discoveries in disease modelling, drug development, and personalized medicine.

Ready to get started? Visit https://ega-archive.org/search/EBiSC to explore the datasets and find more information on requesting access at https://ebisc.org/data/Managed_access_datasets

Posted on Leave a comment

New publication: “The Management of Data for the Banking, Qualification, and Distribution of Induced Pluripotent Stem Cells: Lessons Learned from the European Bank for Induced Pluripotent Stem Cells”

We’re excited to announce the publication of our new paper: “The Management of Data for the Banking, Qualification, and Distribution of Induced Pluripotent Stem Cells: Lessons Learned from the European Bank for Induced Pluripotent Stem Cells”.

This paper provides valuable insights into how EBiSC and the human Pluripotent Stem Cell registry work together to ensure a robust and secure data management platform and present a model for how this could be implemented by other iPSC repositories to increase the FAIRness of iPSC research globally.

This open access publication is linked below – thanks to all authors for their contributions.

https://pmc.ncbi.nlm.nih.gov/articles/PMC10705942

#iPSCs #FAIR #Data #Biobanking

Posted on Leave a comment

A Christmas message from EBiSC

After a very busy year, EBiSC is now entering its next stage as a sustainable scientific repository! Since its inception, EBiSC has garnered a wealth of expertise through the dedication of key partners. This has been maintained via the continued participation of myself at Fraunhofer UK and of the team at Fraunhofer-IBMT, both of whom have been with EBiSC since its inception in 2014. I am delighted to announce that Fraunhofer-UK now spearheads EBiSC, serving as the primary point of contact for users and collaborators, supported by the scientific banking, cryostorage and hPSCreg teams at Fraunhofer-IBMT (both operating as not-for-profit organisations). Moving forward, orders will be processed by Fraunhofer UK, in Scotland, while Fraunhofer-IBMT in Germany will manage the central and mirror storage of cells. EBiSC remains steadfast in its commitment as a not-for-profit repository, diligently collecting and sharing a diverse collection of iPS cell lines, enabling accessibility for researchers worldwide. With this in mind, from the start of 2024 onwards, customers will be able to order directly from the EBiSC catalogue.

EBiSC was initially founded through the collaborative undertaking of large European consortia, funded jointly by the Innovative Medicines Initiative (IMI) of the European Union (EU), and members of the European Federation of Pharmaceutical Industries and Associations (EFPIA). Whilst the first funded project phase, “EBiSC” worked to establish a working infrastructure and framework for the bank, a second phase, “EBiSC2”, aimed to ensure the implemented biobanking framework was robust, sustainable and able to continue operating long term. See more information about the history of EBiSC here.

During EBiSC2, core biobanking operations were performed by Fraunhofer IBMT, Fraunhofer UK and the European Collection of Authenticated Cell Cultures (ECACC, part of the UK Health Security Agency). Whilst ECACC steps away from EBiSC to focus on other developments, we are thankful for their support in implementing the plan for sustainability and I would like to say a big thank you to the whole ECACC team for their time and support during this process. Indeed, we are grateful to all EBiSC and EBiSC2 partners who committed time and energy into not only building the bank, but into making sure that EBiSC can continue collecting and sharing iPS cells and data and providing services to the research community.

EBiSC has many exciting developments in progress and I am looking forward to sharing these during 2024! Wishing you all a very merry Christmas and a great end to the year.

For inquiries or collaboration opportunities with EBiSC, please do not hesitate to reach out.

Best,

Dr Rachel Steeg

Head of EBiSC