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New publication: How FAIR is metadata for human pluripotent stem cells?

EBiSC has been featured in the recent Stem Cell Reports publication, “How FAIR is metadata for human pluripotent stem cells?”, which highlights the importance of applying FAIR principles — Findable, Accessible, Interoperable, and Reusable — to stem cell metadata.

At EBiSC, we share this commitment. As a centralised iPSC repository, we work closely with partners such as hPSCreg to ensure that iPSC line and donor data are standardised, traceable, and accessible to the global research community. Ensuring that iPSC resources are not only available but also discoverable and reusable is essential for accelerating progress in disease modelling, drug discovery, and regenerative medicine.

Explore the paper here:

🔗 https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(25)00248-6

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New publication: “The Management of Data for the Banking, Qualification, and Distribution of Induced Pluripotent Stem Cells: Lessons Learned from the European Bank for Induced Pluripotent Stem Cells”

We’re excited to announce the publication of our new paper: “The Management of Data for the Banking, Qualification, and Distribution of Induced Pluripotent Stem Cells: Lessons Learned from the European Bank for Induced Pluripotent Stem Cells”.

This paper provides valuable insights into how EBiSC and the human Pluripotent Stem Cell registry work together to ensure a robust and secure data management platform and present a model for how this could be implemented by other iPSC repositories to increase the FAIRness of iPSC research globally.

This open access publication is linked below – thanks to all authors for their contributions.

https://pmc.ncbi.nlm.nih.gov/articles/PMC10705942

#iPSCs #FAIR #Data #Biobanking

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A new EBiSC iPSC-derived neuronal cell product simplifies neuroscience research

The possibility to generate an unlimited amount of mature and functionally active neurons from human- induced pluripotent stem cells (iPSCs) has the potential to radically accelerate neuroscience research. However, differentiation protocols can be lengthy, expensive, and often produce inconsistencies in terms of yield and functionality. The European Bank for induced Pluripotent Stem Cells (EBiSC) is happy to announce a new iPSC derived neuronal cell product – EBiSC-NEUR1 which can be used directly from thaw for downstream applications.

https://ebisc.org/EBISC-NEUR1

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Protocol for the use of induced pluripotent stem cells

An updated version of the EBiSC protocol for the use of induced pluripotent stem cells is now available online. This document provides guidance on how to resuscitate, culture and cryopreserve human induced pluripotent stem cells (iPSCs) supplied by EBiSC.

https://ebisc.org/docs/ebisc/EBiSC_User_Protocol_for_Human_induced_Pluripotent_Stem_Cells.pdf

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EBiSC2 and FAIRplus are improving FAIRness of stem cell data

The FAIRplus and EBiSC2 projects are joining forces to improve how ‘FAIR’ standards (Findability, Accessibility, Interoperability and Reusability) can be applied to human induced Pluripotent Stem Cell (iPSC) line data . The joint effort will improve how iPSC line data can be made more findable, standardised and reusable for researchers.

The European Bank for induced Pluripotent Stem Cells (EBiSC) is a centralised, not-for-profit, iPSC bank providing researchers across academia and industry with access to scalable, cost-efficient, and consistent high-quality tools for the development of new medicines. The EBiSC bank collects iPSC lines from European Union (EU) and non-EU countries as well as the accompanied data from individual research groups and makes these available to scientists for research use. FAIRplus delivers guidelines and tools to facilitate the application of ‘FAIR’ principles to data from selected projects, including those funded under the Innovative Medicines Initiative (IMI). Dr Andreas Kurtz, coordinator of the human Pluripotent Stem Cell registry (hPSCreg) and responsible for the EBiSC2 IT infrastructure explains: “By working with FAIRplus, we will make it easier for scientists to find the information they need and improve how we collect, store and standardise data for new cohorts of iPSC lines which are joining the EBiSC collection in the future. This will improve the efficiency and robustness of iPSC-based research and help to accelerate the path to understanding disease pathology and develop new therapeutic opportunities”.

Dr Serena Scollen, project coordinator of FAIRplus says: “The aim of the FAIRplus project is to develop methodologies and tools to increase the FAIRness of biomedical data and demonstrate the added value of the FAIR data management on selected IMI projects, such as EBiSC2. Our hope is that by helping EBiSC2 create fully FAIR datasets, we can support the research community towards more efficient and robust research.”