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New publication: How FAIR is metadata for human pluripotent stem cells?

EBiSC has been featured in the recent Stem Cell Reports publication, “How FAIR is metadata for human pluripotent stem cells?”, which highlights the importance of applying FAIR principles — Findable, Accessible, Interoperable, and Reusable — to stem cell metadata.

At EBiSC, we share this commitment. As a centralised iPSC repository, we work closely with partners such as hPSCreg to ensure that iPSC line and donor data are standardised, traceable, and accessible to the global research community. Ensuring that iPSC resources are not only available but also discoverable and reusable is essential for accelerating progress in disease modelling, drug discovery, and regenerative medicine.

Explore the paper here:

🔗 https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(25)00248-6

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Enabling a Patient-Derived Resource for Angelman Syndrome Research at EBiSC

Angelman syndrome is rare (about 1 in 15,000), but it’s one of the most actionable neurogenetic conditions. The Foundation for Angelman Syndrome Therapeutics (FAST), the largest non-governmental funder of Angelman syndrome research, is turning that potential into tools that labs can use now.

With Yale University and EBiSC, FAST has funded and built a curated panel of Angelman syndrome iPSC lines that reflect the real genetics seen in clinic: full range of AS genotypes, deletion, point mutations, UPD, ICD, and relevant controls. These lines are available for pre-order via EBiSC so teams can move faster on target validation, screening, and mechanism studies.

Explore and request lines: https://ebisc.org/search?q=Yui&disease-super-classes=[]

Interested in working with FAST? Explore their research programs and funding opportunities at www.cureangelman.org/research.

#CureAngelman #AngelmanSyndrome #RareDisease #research #EBiSC

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New iPSC Resource Available for Alzheimer’s Research via EBiSC!

A new study just published in Stem Cell Reports (PMID 40614728) introduces the IPMAR Resource funded by the UK Dementia Research Institute (UKDRI): a collection of human induced pluripotent stem cell (iPSC) lines designed to reflect high and low polygenic risk for Alzheimer’s disease. This comprehensive panel captures extremes of genetic predisposition across early- and late-onset forms of AD, with over a high number of donor-derived lines representing diverse clinical and genetic profiles pubmed.ncbi.nlm.nih.gov+6ukdri.ac.uk+6ebisc.org+6.

Key highlights:

  • Models span high- and low-risk individuals based on global and complement‑pathway AD polygenic risk scores
  • All lines come with linked clinical, longitudinal, and genetic data

🎉 The great news? The iPSC lines are now available through EBiSC, offering a vital tool for disease modelling and further research.

➡️ Learn more and secure access via the EBiSC catalogue. https://ebisc.org/collections/ipmar_alzheimers_disease

📩 For inquiries or collaboration opportunities, feel free to get in touch.

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Congenital Muscular Dystrophy collection now available via EBiSC.

Skeletal muscle laminopathies are rare genetic disorders caused by pathogenic mutations in the LMNA gene, leading to progressive muscle weakness and other severe symptoms. This study by researchers at UCL demonstrates the use of iPSCs carrying LMNA mutations to model these conditions, offering valuable insights into disease mechanisms and therapeutic opportunities.

We’re pleased to share that CureCMD have now made the iPSC lines featured in this research available through EBiSC. These lines provide an essential tool for researchers studying laminopathies and advancing treatments for these challenging disorders.

Access the collection and learn more here. Let’s drive innovation in skeletal muscle disease research!

#Laminopathies #SkeletalMuscleResearch #iPSC #EBiSC #Genetics #DiseaseModeling #RareDiseases

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Focal Segmental Glomerulosclerosis (FSGS) iPSCs and clinical data

We’re happy to share that the iPSC lines from the study “Generation of 20 Human Induced Pluripotent Stem Cell Lines from Patients with Focal Segmental Glomerulosclerosis (FSGS)” are available through EBiSC!

These iPSC lines, derived from patients with FSGS, provide a valuable resource for studying kidney disease mechanisms and testing potential therapies. Detailed clinical data is available upon request for researchers looking to deepen their understanding of FSGS.

Explore the iPSC lines and access data via EBiSC here to drive forward your nephrology research.

#FSGS #iPSC #KidneyResearch #EBiSC #GeneticResearch #DiseaseModeling #Nephrology #RegenerativeMedicine

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Exciting Partnership Announcement: EBISC Teams Up with Sampled to Support USA Shipments for iPSC Resources

Exciting Partnership Announcement: EBISC Teams Up with Sampled to Support USA Shipments for iPSC Resources

EBISC (European Bank for Induced Pluripotent Stem Cells) has teamed up with Sampled, a global leader in biorepository and laboratory services, to enhance distribution capabilities for American researchers.

What This Means for Researchers

For American researchers, this partnership will simplify the procurement process for iPSC resources, allowing them to focus more on their research objectives and less on logistics. The enhanced local distribution ensures that high-quality samples can be efficiently shipped, helping to save time and reducing the cost of shipping.

Looking Ahead

As this exciting collaboration unfolds, we are confident that it will significantly improve the availability and accessibility of iPSC resources for researchers in the United States. This partnership represents a key step toward creating a more connected and efficient global research ecosystem.

Stay tuned for further updates on how EBISC and Sampled are working together to support scientific discovery and innovation. We look forward to seeing the incredible advancements that will come from this new chapter in research collaboration.

For more information on how this partnership will benefit your research, visit EBISC and Sampled.

EBiSC – European Bank for Induced pluripotent Stem Cells

Sampled – Any Sample, Every Answer.

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New publication on EBiSC-NEUR1 neurons!

We’re thrilled to see the paper “Measurements of Neurite Extension and Nucleokinesis in an iPSC-Derived Model System Following Microtubule Perturbation” published, showcasing the power of EBiSC iPSC-derived neurons.

This study highlights how iPSC technology can be used to model and measure key cellular processes like neurite extension and nucleokinesis, offering valuable insights into neurodevelopmental diseases. It’s exciting to see how EBiSC-generated iPSC lines are contributing to cutting-edge research that deepens our understanding of cellular dynamics and disease mechanisms.

https://pubmed.ncbi.nlm.nih.gov/39602292

#iPSC #Neurodegeneration #Neuroscience #EBiSC #DiseaseModeling #StemCellResearch #Neurodevelopment

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Simplified and secure access to genomic data at EBiSC.

At EBiSC, we’re constantly working to make it easier for researchers to access and use our valuable resources. That’s why we’ve streamlined the process for requesting and accessing genomic data associated with our iPSC lines.

Via EGA, researchers can now easily request genomic datasets linked to our iPSC lines, including genomic, and clinical data. We’ve worked hard to ensure that this data is not only comprehensive but also easily accessible, so researchers can focus on what matters most: advancing their research.

Our goal is to make high-quality iPSC resources and data available to the scientific community to drive innovation and accelerate discoveries in disease modelling, drug development, and personalized medicine.

Ready to get started? Visit https://ega-archive.org/search/EBiSC to explore the datasets and find more information on requesting access at https://ebisc.org/data/Managed_access_datasets

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A panel of robust and well characterised iPSC lines from apparently healthy backgrounds.

We understand that finding the perfect, well-characterised iPSC line from a healthy background can be a challenge. That’s why EBiSC has curated a special panel of robust iPSC lines—covering both male and female genetic backgrounds and generated using various reprogramming methods—to make your research easier. Explore the full panel of healthy iPSC lines here and reach out if you have any questions—we’re here to help!

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New publication: “The Management of Data for the Banking, Qualification, and Distribution of Induced Pluripotent Stem Cells: Lessons Learned from the European Bank for Induced Pluripotent Stem Cells”

We’re excited to announce the publication of our new paper: “The Management of Data for the Banking, Qualification, and Distribution of Induced Pluripotent Stem Cells: Lessons Learned from the European Bank for Induced Pluripotent Stem Cells”.

This paper provides valuable insights into how EBiSC and the human Pluripotent Stem Cell registry work together to ensure a robust and secure data management platform and present a model for how this could be implemented by other iPSC repositories to increase the FAIRness of iPSC research globally.

This open access publication is linked below – thanks to all authors for their contributions.

https://pmc.ncbi.nlm.nih.gov/articles/PMC10705942

#iPSCs #FAIR #Data #Biobanking