A new study just published in Stem Cell Reports (PMID 40614728) introduces the IPMAR Resource funded by the UK Dementia Research Institute (UKDRI): a collection of human induced pluripotent stem cell (iPSC) lines designed to reflect high and low polygenic risk for Alzheimer’s disease. This comprehensive panel captures extremes of genetic predisposition across early- and late-onset forms of AD, with over a high number of donor-derived lines representing diverse clinical and genetic profiles pubmed.ncbi.nlm.nih.gov+6ukdri.ac.uk+6ebisc.org+6.
Key highlights:
- Models span high- and low-risk individuals based on global and complement‑pathway AD polygenic risk scores
- All lines come with linked clinical, longitudinal, and genetic data
🎉 The great news? The iPSC lines are now available through EBiSC, offering a vital tool for disease modelling and further research.
➡️ Learn more and secure access via the EBiSC catalogue. https://ebisc.org/collections/ipmar_alzheimers_disease
📩 For inquiries or collaboration opportunities, feel free to get in touch.